Improved methods to assess membrane protein stability provide insight into the nature of substrate, ligand and lipid interactions

Membrane proteins account for up to 30% of the proteins present in an organism, though relatively few are well characterised compared to their soluble protein counterparts. This is largely due to their instability when extracted from membranes using detergent, which hampers their study. New straightforward and reliable methods are required to assess the integrity of extracted protein.



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